Molybdenum cofactor biosynthesis protein MoaC.

The molybdenum cofactor (Moco) is an essential component of a large family of enzymes involved in important transformations in carbon, nitrogen and sulfur metabolism. The Moco biosynthetic pathway is evolutionarily conserved and found in archaea, eubacteria and eukaryotes. In humans, genetic deficiencies of enzymes involved in thispathway trigger an autosomal recessive and usually deadly disease with severe neurological symptoms. The MoaC protein,together with the MoaA protein, is involved in the first step of Moco biosynthesis. (from paper abstract)

Wuebbens et al. Structure Fold.Des. 8: 709-717

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